In mice, genes for albinism (a), chronic inflammation (i), and reduced sense of smell (r) are linked. You initially crossed a mouse that is homozygous dominant for all three traits with a mouse that is homozygous recessive for all three traits. You then crossed several of the resulting F1 offspring to mice that are homozygous recessive for all three traits. You observe the following phenotypes in the offspring:
colored, healthy, normal smell sense:22
albino, chronically inflamed, reduced smell sense:23
colored, chronically inflamed, reduced smell sense:5
albino, healthy, normal smell sense:6
colored, healthy, reduced smell sense:0
albino, chronically inflamed, normal smell sense:1
colored, chronically inflamed, normal smell sense:6
albino, healthy, reduced smell sense:7
a. Diagram a map between the genes and calculate the map distances.
b. If the interference of these genes is 0.43, how many more F2 progeny will you need to observe to see at least 2 of each double recombinant?
c. What are your expected numbers of each single crossover after you have observed the total number of mice calculated in part (b)?
d. If a fourth gene (z) exhibits 54% recombination with gene i, 35% recombination with gene a and 51% recombination with gene r, will this gene be on the same chromosome or a separate chromosome? If gene z is on the same chromosome as the other three genes, indicate its location by copying and modifying your genetic map from part (a).
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